After pushing back his decision until mid-May, Jefferson, a top 25 prospect out of Wynnewood (Pa.) Friends Central, picked Duke at a press conference at his school on Tuesday.
"When I finally sat down and talked to my family Duke just seemed like the right school and the best fit," Jefferson said at the media conference.
"It's a place where everyone would be happy and seeing me going," said Jefferson. "They value academics... right now I don't think they have a player at my position or a guy like me at Duke right now and I hope to bring an energy and a passion to the school and basketball team."
With his commitment to the Blue Devils, Jefferson becomes the second five-star prospect to commit to Duke in the 2012 class. Jefferson joins the top shooting guard in the country -- Rasheed Sulaimon -- to make up their two-man class.
Jefferson is ranked as the No. 3 power forward and No. 21 overall in the 2012 class.
*James Henderson also contributed to this report.